Healthcare
In Silico Reference File Working Group
Exploring new approaches for molecular diagnostic quality assurance
In late 2022, Tapestry Networks and a select group of stakeholders convened an informal working group to advance further exploration of the pilot’s dry lab or in silico component. In silico reference files (ISRFs) are economical materials that laboratories and test developers can use to assess bioinformatics pipeline performance to support next-generation-sequencing test development, validation, and quality assurance.
In 2023, the effort explored potential use of ISRFs during clinical trials in cases where trials employ multiple clinical trial assays to enroll patients. Tapestry and partners continue to assess opportunities for better understanding ISRF use and their value in molecular diagnostic quality assurance, as well as the use of diverse assays in clinical trials.
